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首页 > 学术中心 > 学术ASAP > 【电纺进展】静电纺琥珀蚕蚕丝蛋白纳米纤维毡应用于皮肤组织工程
 

【电纺进展】静电纺琥珀蚕蚕丝蛋白纳米纤维毡应用于皮肤组织工程

 
发布日期:2016-07-06     来源:永康乐业
 

文献题目:Fabrication of robust Antheraea assama fibroin nanofibrous mat using ionic liquid for skin tissue engineering.

作者:Chandra Mohan Srivastava, Roli Purwar

刊物名称:Materials Science and Engineering: C,Volume 68, Pages 276-290

上线时间:10 May 2016

Abstract                                          

Electrospinning is an emerging technique used for fabrication of nanofibrous mats for skin tissue engineering applications. The aim of this study centered on fabrication of muga fibroin electrospun mats by using ionic liquid and its characterizations. The muga fibroin extracted from cocoon of Antheraea assama is dissolved in 1-butyl, 3-methyl imidazolium acetate (BMIMAc), a green solvent, to prepare a dope solution for electrospinning. The molecular weight, rheology and structural properties of dope solution are characterized. The process parameters of electrospinning machine such as voltage and concentration of dope solution are varied to obtain nanofibrous mats. The nanofibrous mat having average fiber diameter of 160 nm are obtained from 10% w/v concentration of muga fibroin in BMIMAc with an applied voltage of 20 KV. The mechanical, structural, physical and thermal properties of muga nanofibrous mat (MNF) are analyzed and compare with muga cast film. The cytocompatibility test is performed using L929 fibroblast cells. It is observed that muga nanofibrous mat support higher growth of fibroblast cells (p < 0.05) as compared to muga cast film (MCF). Muga nanofibrous mat and cast film are loaded with gentamycin sulphate. The release rate and antimicrobial efficiency of gentamycin sulphate loaded muga nanofibrous mat are found to be significantly higher (p < 0.05) as compared to muga cast film. All these results indicate that muga nanofibrous mat would be a promising material for skin tissue engineering.

评论:这篇文章通过静电纺丝法成功制备出从茧中提取的琥珀蚕蚕丝蛋白纳米纤维毡,优化了琥珀蚕蚕丝蛋白-离子溶液的加工参数;纳米纤维毡展现了比琥珀蚕浇铸膜更好的物理力学性能和生物学性能;这种纳米纤维垫将是一个有前途的材料应用于皮肤组织工程。
 
 
 

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